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Hold mechanisms and the neural integrator in DYT-TOR1A (DYT-1) dystonia

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Despite being a disorder of posture the neural control of holding is rarely systematically examined.  By varying

sensory feedback we have been able to develop a model behind the hold instability in dystonia.  Experiments have been developed using a robot at UCL within John Rothwell’s lab and the work represents an international collaboration with motor control scientists Joseph Galea and Reza Shadmehr